Examining the Impact of Evening Primrose oil on (Oenothera biennis) on Fertility in male Wister rats induced with Sodium arsenite
Keywords:
Sodium Arsenite, Fertility Enhancing Activity, Evening Primrose OilAbstract
Science of health care now includes herbal remedies as fundamental component. Their conventionally used therapeutic products were from plants. Male fertility-enhancing activity of Oenothera biennis oil was investigated. In this study for 60 days in male Wister rats that were rendered infertile by sodium arsenite. The parameters assessed included semen pH, volume, sperm count, viability, motility, sperm progressive assessment, sperm morphology, histopathological investigations, and antioxidant studies. 24 male Albino Wister rats of 171g, aged 4 weeks, were chosen to mate with same number of female rats (n=24). Twenty-four male Wister rats treated with sodium arsenite (10 mg/kg) and divided into two groups (I-IV). Every group received 0.5 ml and 1 ml of E. P. O. for one instance every sixty days, while control groups received distilled water daily.Each group of animals was paired with female rats for a duration of seven days. Day 8 saw successful mating of male rats. Semen was gathered for examination of spermatogenic strictures, and the testicular supernatants were ready for evaluation of antioxidant parameters and testicular function indices. Administration of 0.5 mL/kg/day and 1 mL/Kg/Day EPO for 60 days resulted in related to the amount administereddecreases in pattern of mass improvement, by greatest effect being noted (p < 0.05) On the other hand, EPO showed significant dose-dependent increases (p < 0.001) in the percentage of living sperm and total sperm count, but percentage of dead sperm and aberrant sperm showed opposite effects. Overall, higher spermatogenesis, steroidogenesis, antioxidant activity observed throughout a 60-day prolonged oral therapy with 0.5 and 1 mL/kg body of EPO.
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Articles published in the Journal of Biomedical and Pharmaceutical Insights (JBPI) are licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
