IN-VITRO CHARACTERIZATION AND EVALUATION OF GASTRORETENTIVE FLOATING HBS CAPSULES OF GLICLAZIDE FOR SUSTAIN DRUG RELEASE
Keywords:
Gastroretentive, Floating, HBS, FTIRAbstract
The present research work attempted to formulation, characterization and evaluation of gastroretentive floating HBS (Hydrodynamically Balance System) capsules of gliclazide for sustain drug release. These floating HBS capsules of gliclazide were formulated by using two suitable polymer cationic charge chitosan and anionic charge xanthan gum with the help of physical blending and filled in capsules. Different evaluation parameters like their weight uniformity, drug content uniformity, swelling index of all formulation showing good results to develop the system. In vitro floatation and in vitro drug release studies also prove that all these formulation specially formulation GFC4 showing better drug release which is more than 10 hours due to suitable ratio using polymeric blend as well as formation of polyelectrolyte complex between two opposite charge polymers. It is also confirmed that there are no more incompatibility produce between drug and polymers by the help of FTIR also help to develop the system. So, these types of gastroretentive floating HBS capsules will be very effective for gastroretentive sustain drug release.
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Copyright (c) 2026 Radheshyam Samanta (Author)
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Articles published in the Journal of Biomedical and Pharmaceutical Insights (JBPI) are licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
